Table 4.
Demographic, surgical variables and clinical outcomes of RFWB group versus component therapy (controls) for Norwood patients only
| RFWB (n = 6) | Control (n = 10) | P value | |
|---|---|---|---|
| Primary outcome measures | |||
| Gender (male) | 1/6 | 5/10 | .20 |
| Age (d) | 10 (3–30) | 9 (5–33) | .79 |
| Weight (kg) | 3.5 ± 0.5 | 3.4 ± 0.4 | .28 |
| Mean CBP time, min ± SD | 128 ± 28 | 122 ± 23 | .92 |
| Mean aortic crossclamp time, min ± SD | 71 ± 16 | 61 ± 11 | .14 |
| Median circulatory arrest time, min | 8 (3–13) | 2 (0–25) | .07 |
| Mean OR time, min ± SD | 372 ± 69 | 402 ± 39 | .08 |
| Chest tube loss 0–4 h CCCU, mL/kg (range) | 9.0 (7.7–29.4) | 9.8 (4.3–53.4) | .75 |
| Chest tube loss 4–24 h CCCU, mL/kg (range) | 10.3 (4.3–33.1) | 13.4 (4.1–51.7) | .45 |
| Bleeding assessed as moderate or severe | 2/6 | 9/10 | .04 |
| Inotropic support score (ISS) at 4 h CCCU | 9.1 (0.0–19.9) | 6.6 (5.0–16.9) | .73 |
| Inotropic support score (ISS) at 24 h CCCU | 5.0 (0.0–6.6) | 8.5 (0.0–11.6) | .06 |
| Ventilation in hours, median (range) | 264 (163–361) | 170 (121–380) | .39 |
| CCCU LOS in days, median (range) | 12 (7–19) | 9 (6–16) | .36 |
| Hospital LOS in days, median (range) | 22 (17–36) | 21 (16–25) | .42 |
| Blood product exposure, mean units ± SD | 3.8 ± 1.5 | 7.0 ± 2.7 | .01 |
| Transfusion requirements postop, mL/kg (range) | 103 (0–177) | 37 (16–102) | .13 |
| Age of donor blood products in days | 1.5 ± 0.5 | 15.1 ± 9.3 | .001 |
RFWB, Reconstituted fresh whole blood; CPB, cardiopulmonary bypass; SD, standard deviation; OR, operating room; CCCU, cardiac critical care unit; LOS, length of stay.