Table 1.
Inhibitory effects of four polyoxotungstates against several ortho- and paramyxoviruses
| Virus and cell | EC50 and IC50 of polyoxotungstates(μM) a |
||||
|---|---|---|---|---|---|
| HS-054 | HS-058 | HS-106 | HS-158 | Ribavirin | |
| Antiviral activity | |||||
| FluV-A H3N2 | 0.6 | 1.4 | 2.8 | 2.8 | 3.7 |
| (Ishikawa) c | (0.37–0.94) | (0.7–2.0) | (1.3–5.4) | (1.0–5.5) | (1.8–7.0) |
| FluV-B | 35.5 | 13.9 | 45.7 | 36.5 | 5.1 |
| (Singapore) | (20–54) | (8.7–21.8) | (19.4–68) | (30–43) | (1.8–5.2) |
| RSV-A | 2.8 | 5.6 | 9.8 | 14.2 | 4.7 |
| (Long) | (1.4–4.5) | (2.4–13.5) | (9.0–10.3) | (8.3–24.4) | (1.5–9.7) |
| RSV-B | 7.8 b | 3.1 b | 4.5 b | 2.7 b | 1.6 b |
| (SM-61-48) | |||||
| MLSV | 0.3 | 0.8 | > 35.5 | 1.4 | 5.2 |
| (Edmonston) | (0.2–0.4) | (0.76–0.85) | (6.6–50) | (1.2–1.6) | (1.9–10) |
| MPSV | 20.6 | > 50 | > 50 | > 50 | 3.4 |
| (EXCH-3) | (15.5–20) | (3.4–7.1) | |||
| PfluV-2 | 1.8 | 0.43 | 7.8 | 24.1 | 8.9 |
| (Greer) | (1.5–2.1) | (0.32–0.54) | (2.6–16.1) | (23.2–25) | (6.4–11.2) |
| PfluV-3 | 28.0 | > 50 | > 50 | > 50 | 17.2 |
| (C243) | (25–31) | (16.4–18.0) | |||
| Cytotoxicity | |||||
| MDCK | > 200 | > 200 | > 200 | 164 | > 200 |
| HEp-2 | 88 | > 200 | > 200 | 82.7 | 52.7 |
| HMV-2 | > 200 | 50 | 20.7 | 53.7 | > 100 |
| Vero | 50 | 50 | 148 | > 200 | 100 |
a
Determined by MTT method. Values are averages of three or four independent experiments. Numbers in parentheses show the ranges of values.
b
Data from one experiment.
c
In parenthesis the names of the virus strains were shown.