Table 1.
Virus and cell | EC50 and IC50 of polyoxotungstates(μM) a |
||||
---|---|---|---|---|---|
HS-054 | HS-058 | HS-106 | HS-158 | Ribavirin | |
Antiviral activity | |||||
FluV-A H3N2 | 0.6 | 1.4 | 2.8 | 2.8 | 3.7 |
(Ishikawa) c | (0.37–0.94) | (0.7–2.0) | (1.3–5.4) | (1.0–5.5) | (1.8–7.0) |
FluV-B | 35.5 | 13.9 | 45.7 | 36.5 | 5.1 |
(Singapore) | (20–54) | (8.7–21.8) | (19.4–68) | (30–43) | (1.8–5.2) |
RSV-A | 2.8 | 5.6 | 9.8 | 14.2 | 4.7 |
(Long) | (1.4–4.5) | (2.4–13.5) | (9.0–10.3) | (8.3–24.4) | (1.5–9.7) |
RSV-B | 7.8 b | 3.1 b | 4.5 b | 2.7 b | 1.6 b |
(SM-61-48) | |||||
MLSV | 0.3 | 0.8 | > 35.5 | 1.4 | 5.2 |
(Edmonston) | (0.2–0.4) | (0.76–0.85) | (6.6–50) | (1.2–1.6) | (1.9–10) |
MPSV | 20.6 | > 50 | > 50 | > 50 | 3.4 |
(EXCH-3) | (15.5–20) | (3.4–7.1) | |||
PfluV-2 | 1.8 | 0.43 | 7.8 | 24.1 | 8.9 |
(Greer) | (1.5–2.1) | (0.32–0.54) | (2.6–16.1) | (23.2–25) | (6.4–11.2) |
PfluV-3 | 28.0 | > 50 | > 50 | > 50 | 17.2 |
(C243) | (25–31) | (16.4–18.0) | |||
Cytotoxicity | |||||
MDCK | > 200 | > 200 | > 200 | 164 | > 200 |
HEp-2 | 88 | > 200 | > 200 | 82.7 | 52.7 |
HMV-2 | > 200 | 50 | 20.7 | 53.7 | > 100 |
Vero | 50 | 50 | 148 | > 200 | 100 |
Determined by MTT method. Values are averages of three or four independent experiments. Numbers in parentheses show the ranges of values.
Data from one experiment.
In parenthesis the names of the virus strains were shown.