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. 2006 May 24;60(5):211–219. doi: 10.1016/j.biopha.2006.03.009

Table 4.

PM 523 resistant strains and amino acid changes in HA of the resistant strains

EC₅₀ (μM) ^a
Virus stock	MTT	Plaque reduction	Amino acid substitution
Parent ^b	8.7 ± 1.2	6.6 ± 0.8
R-1 ^c	71.4 ± 6.8	74.5 ± 10.2	Lys189Asn, Ile202Thr
R-2 ^c	67.8 ± 6.5	73.6 ± 10.8	Ile202Thr
R-4 ^c	79.0 ± 10.2	88.1 ± 9.9	Ile202Thr
R-b ^d	63.0 ± 7.0	66.7 ± 6.2	Lys189Asn
R-c ^d	80.3 ± 6.8	78.9 ± 9.4	Lys189Asn, Ile202Val

^a

Values are averages of three independent experiments.

^b

Ishikawa/AH3N2/(plaque purified) strain.

^c

Progenies of the parent strain.

^d

Progenies of a wild Ishikawa strain.