Table 4.
EC50 (μM) a | |||
---|---|---|---|
Virus stock | MTT | Plaque reduction | Amino acid substitution |
Parent b | 8.7 ± 1.2 | 6.6 ± 0.8 | |
R-1 c | 71.4 ± 6.8 | 74.5 ± 10.2 | Lys189Asn, Ile202Thr |
R-2 c | 67.8 ± 6.5 | 73.6 ± 10.8 | Ile202Thr |
R-4 c | 79.0 ± 10.2 | 88.1 ± 9.9 | Ile202Thr |
R-b d | 63.0 ± 7.0 | 66.7 ± 6.2 | Lys189Asn |
R-c d | 80.3 ± 6.8 | 78.9 ± 9.4 | Lys189Asn, Ile202Val |
Values are averages of three independent experiments.
Ishikawa/AH3N2/(plaque purified) strain.
Progenies of the parent strain.
Progenies of a wild Ishikawa strain.