Table 8.
Antiviral activities of polyoxometalates against coronaviruses
| EC50(μM) a |
SI e |
|||||
|---|---|---|---|---|---|---|
| TGEV b | FIPV c | SARS-V d | TGEV | FIPV | SARS-V | |
| PM-504 | 1.4 ± 0.5 | 0.4 ± 0.3 | 3.5 ± 2.4 | > 12.8 | > 46.7 | > 14.3 |
| PM-518 | 2.1 ± 1.1 | > 32.9 | > 50 | > 15.6 | □1.0 | < 1.0 |
| PM-520 | 1.4 ± 1.3 | 0.76 ± 0.5 | 4.9 ± 1.4 | > 20.4 | >38.5 | > 10.3 |
| PM-523 | 2.5 ± 0.6 | > 32.0 | > 50 | > 32.0 | □1.0 | < 1.0 |
| PM-802 | 0.5 ± 0.5 | 0.03 ± 0.01 | > 50 | 4.9 | 97.2 | < 1.0 |
| PM-803 | 0.34 ± 0.3 | > 21.0 | Nd | 55.3 | □1.0 | – |
| PM-1001 | 0.14 ± 0.1 | 0.2 ± 0.1 | 0.7 ± 0.4 | 83.6 | 84.4 | > 70.4 |
| PM-1002 | 0.6 ± 0.4 | Nd | 0.25 ± 0.07 | 18.6 | – | > 400 |
| PM-1201 | 0.2 ± 0.14 | > 9.0 | Nd | > 100 | □1.0 | – |
| PM-1207 | 1.9 ± 1.4 | 0.09 ± 0.04 | 0.9 ± 0.24 | > 9.3 | 35.2 | > 54.3 |
| PM-1208 | 2.0 ± 1.8 | > 3.6 | 2.7 ± 0.6 | > 8.1 | □1.0 | > 18.4 |
| PM-1210 | 1.6 ± 1.1 | 0.74 ± 0.4 | 0.76 ± 0.3 | > 6.6 | > 14.3 | >65.8 |
| PM-1213 | 1.7 ± 1.0 | > 10.5 | 0.47 ± 0.14 | > 18.2 | □1.0 | 106.4 |
a
EC50 and CC50 were determined by the average of three independent experiments.
b
Transmissible gastroenteritis virus of swine.
c
Feline infectious peritonitis virus.
d
SARS coronavirus.
e
Selectivity index. SIs were calculated by CC50/EC50 in which the CC50s were determined by cytotoxicities for CPK cells (TGEV), for fcwf-4 cells (FIPV) and for Vero cells (SARS-V), respectively. The SIs greater than 30 are indicated in bold face.