Table 2.
Antimicrobial agents classified by pattern of bactericidal activity
| Drug class | Pharmacodynamic class | Therapeutic goal (for S pneumoniae) |
|---|---|---|
| β-LactamsPenicillinsCephalosporins | Time-dependent | Time above MIC >40%-50% of the dosing interval |
| MacrolidesErythromycinClarithromycinAzithromycin | Time-dependent (with moderate to prolonged persistent effect) | AUC-to-MIC ratio of 25–35 |
| Ketolides | ||
| Telithromycin | Concentration-dependent | Unknown∗ |
| Fluoroquinolones | Concentration-dependent (with prolonged persistent effect) | AUC-to-MIC ratio of 25–35 |
| Gatifloxacin | ||
| Levofloxacin | ||
| Moxifloxacin | ||
∗
Further research is needed.