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. 2020 Apr 3;13(Suppl 5):48. doi: 10.1186/s12920-020-0674-5

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Significant modules of dual evaluation regarding IMSGC GWAS as discovery set. The top module of dual evaluation shows MAPK1 as central (a). Modules are regarded as significant based on normalized evaluation and discovery z-scores. Significant modules are represented in red (b). The 20 significant modules were merged to show overall gene network (n = 56) (c). Large nodes represent central genes and small nodes represent less central genes (based on measure of Betweenness). Colors of nodes represent Pascal reported gene-level p-values as specified by legend