Table 1.

Gene set enrichment analysis of the modules from dual evaluation^a

GO term	# contributing genes/ term sizeb	Contributing genesc	p-value	adj. p-valued
Molecular Function
Phosphotyrosine residue binding	3/18	GRB2, MAPK1, MAPK3	1.916 × 10− 5	1.674 × 10− 3
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	4/62	CD80, CD86, GRB2, PIK3R2	3.318 × 10− 5	1.674 × 10− 3
Virus receptor activity	4/71	CD80, CD86, ITGB3, TNFRSF14	5.667 × 10−5	1.674 × 10−3
Phosphatidylinositol bisphosphate kinase activity	4/72	CD80, CD86, GRB2, PIK3R2	5.987 × 10−5	1.674 × 10−3
Protein phosphorylated amino acid binding	3/28	GRB2, MAPK1, MAPK2	7.533 × 10−5	1.674 × 10−3
Biological Process
T cell costimulation	7/82	CD80, CD86, CSK, CTLA4, GRB2, MAP3K14, TNFRSF14	3.704 × 10−9	2.113 × 10−6
Lymphocyte costimulation	7/83	CD80, CD86, CSK, CTLA4, GRB2, MAP3K14, TNFRSF14	4.037 × 10−9	2.113 × 10−6
JAK-STAT cascade involved in growth hormone signaling pathway	4/15	MAPK1, MAPK3, STAT3, STAT5A	8.415 × 10−8	2.937 × 10−5
Growth hormone receptor signaling pathway	4/24	MAPK1, MAPK3, STAT3, STAT5A	6.425 × 10−7	1.598 × 10− 4
Cellular response to growth hormone stimulus	4/25	MAPK1, MAPK3, STAT3, STAT5A	7.633 × 10−7	1.598 × 10−4
Cellular Component
Nuclear pore	5/84	KPNB1, NUP153, RAN, SENP2, SNUPN	4.311 × 10−6	3.794 × 10−4
Clathrin-coated pit	4/69	AMN, CLTC, EPN1, EPS15L1	4.666 × 10−5	2.053 × 10−3
Endoplasmic reticulum tubular network	2/12	KPNB1, RAB18	5.296 × 10−4	0.0136
Platelet alpha granule membrane	2/13	ITGB3, PECAM1	6.248 × 10−4	0.0136
Cytosolic large ribosomal subunit	3/67	RPL4, RPL5, RPL17	9.556 × 10−4	0.0136

^aIn this dual evaluation, IMSGC GWAS was the discovery set and GeneMSA was the evaluation set

^bContributing genes: the number of genes in the input gene set. Term size: the total number of genes in the corresponding GO term

^cContributing genes: those in the input genes that contributed to the enrichment

^dAdjusted p-value by the Benjamini-Hochberg method [28]