Table 4.

Mouse Common Inflammatory Response Cluster of Nine Genes

Gene	Name	GO and functional annotations	Mouse cell type⁎	Observed mean fold increase
Saa3	Serum amyloid A 3	Acute phase response activity, lipid transporter activity	Macrophage	7.1 in CLP blood 5.1 in LPS blood 7.3 in CLP spleen
NGP	Neutrophilic granule protein	Antimicrobial peptide activity, enzyme inhibitor activity	Neutrophil	4.1 in CLP blood 3.8 in LPS blood 1.7 in CLP spleen
S100A8	S100 Calcium-binding protein A8 (calgranulin A)	Metal ion binding	Neutrophils, B cells, dendritic cells	3.7 in CLP blood 4.8 in LPS blood 3.5 in CLP spleen
S100A9	S100 Calcium-binding protein A9 (calgranulin B)	Metal ion binding, signal transducer activity	Neutrophils, B cells, dendritic cells, monocytes	4.4 in CLP blood 5.2 in LPS blood 3.0 in CLP spleen
IRF7	Interferon regulatory factor 7	RNA polymerase transcription factor activity	T cells	1.8 in CLP blood 1.9 in LPS blood 1.3 in CLP spleen
ID2	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	Nucleus, development; required for NK cell commitment; negatively regulates B-cell differentiation	B cells, NK cells	2.5 in CLP blood 2.8 in LPS blood 2.1 in CLP spleen
LCN2	Lipocalin 2 (oncogene 24p3)	Binding, transporter activity	Neutrophils	7.2 in CLP blood 8.5 in LPS blood 7.7 in CLP spleen
FPRL1	Formyl peptide receptor-like 1	Receptor activity	Neutrophils, splenocytes	5.7 in CLP blood 5.7 in LPS blood 1.3 CLP spleen
EST	Unknown	Unknown	Unknown	3.0 in CLP blood 2.3 in LPS blood 1.8 in CLP spleen

CLP, cecal ligation and puncture; LPS, lipopolysaccharide; NK, natural killer.

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