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Esculetin inhibit glucose consumption and lactate production, and are toxic to cells. (A) The survival of HepG2 cells exposed to 0–200 µM esculetin within 1 h. (B, C) Concentration-dependent inhibition of glucose consumption and lactate production in HepG2 cells by esculetin within 1 h. (D) Time-dependent survival of HepG2 cells exposed to 200 µM esculetin. (E) Sensitivity of HepG2 cells in 8 h toward series concentration of esculetin. Data are mean ± SD (n=3), *P < 0.05, **P < 0.01.
