Fig. 11.

Up- and downregulation of NR2B in the SDH and hippocampus, respectively, were normalized by L-TAMS. Western blot analysis showed that NR2B was upregulated in the SDH (a) but downregulated in the hippocampus (b) of cystitis model rats at the three time points (days 8, 12, and 20 after the first CYP injection). The abnormal expression of NR2B in the SDH (c) or hippocampus (d) was neutralized by oral application of L-TAMS on day 20. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. Veh group, ^#P < 0.05 and ^##P < 0.01 vs. CYP group. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test