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. 2020 Apr 2;17:99. doi: 10.1186/s12974-020-01786-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Inhibition of NF-κB signaling attenuated mechanical allodynia, depressive-like behavior, and STMD in CYP-induced cystitis model. a Intrathecal injection of pyrrolidinedithiocarbamate ammonium (PDTC), an inhibitor of NF-κB signaling, substantially attenuated mechanical allodynia from day 12 after the first CYP injection. After day 15, the mechanical withdrawal threshold of the CYP + PDTC group became non-significantly different from that of the vehicle group. The data were analyzed by two-way ANOVA followed by the Tukey post hoc test. b Treatment with PDTC significantly reversed the depressive-like behavior of cystitis rats, indicated by a longer floating time in the FST. c The recognition index in the NORT was reduced in cystitis rats, which was normalized by PDTC treatment. The data in band c were analyzed by one-way ANOVA followed by the Tukey post hoc test. n = 7 per group in the von Frey test. n = 5 per group in the FST and NORT. **P < 0.01 and ***P < 0.001 vs. Veh group. ^##P < 0.01 and ^###P < 0.001 vs. CYP group