Table 2.

Differentially expressed proteins between major depressive disorder and bipolar disorder

Majority protein IDs	Protein names	Gene names	Fold changea	Student’s t-test statistics (t)	p-valueb
Overexpressed in MDD
P51149;C9J592;C9J8S3	Ras-related protein Rab-7a	RAB7A	2.729	5.975	4.3 * 10−6
E9PF63;O75116	Rho-associated protein kinase 2	ROCK2	2.321	4.782	8.0 * 10−5
P01763	Ig heavy chain V-III region WEA	IGHV3–48	1.205	3.668	0.001
P08571;D6RFL4	Monocyte differentiation antigen CD14;Monocyte differentiation antigen CD14, urinary form;Monocyte differentiation antigen CD14, membrane-bound form	CD14	1.266	2.875	0.009
P23083	Ig heavy chain V-I region V35	IGHV10R15–1	2.103	2.739	0.011
A0A075B6Q5	Ig heavy variable 3–64	IGHV3–64	2.252	2.698	0.013
P01780	Ig heavy chain V-III region JON	IGHV3–7	0.941	2.404	0.025
Overexpressed in BD
E7ESC6;Q9UIA9	Exportin-7	XPO7	−2.999	−4.520	1.5 * 10−4
P03950	Angiogenin	ANG	−1.714	−3.636	0.001
A0A075B6J4	Ig lambda variable 3–25	IGLV3–25	−2.550	−3.326	0.003
Q96Q89–4;Q96Q89–3;Q96Q89;Q96Q89–2	Kinesin-like protein KIF20B	KIF20B	−1.298	−2.718	0.012
A0A096LPE2;P35542;A0A087X0E2	Serum amyloid A-4 protein; Serum amyloid A protein	SAA2-SAA4;SAA4	−0.660	−2.640	0.015
P05160	Coagulation factor XIII B chain	F13B	−1.120	−2.315	0.030
D6REX5;P49908;D6RIS9	Selenoprotein P	SEPP1;SELENOP	−0.881	−2.088	0.048

Abbreviations: MDD major depressive disorder, BD bipolar disorder

^aFold change calculated by the difference of the logarithmic₍₂₎ transferred intensity

^bBoldface p-values are significant when adjusting for multiple comparison by using the Benjamini-Hochberg FDR adjusted p-value