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. 2014 Apr 24;107:35–41. doi: 10.1016/j.antiviral.2014.04.004

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Copyright © 2014 Elsevier B.V. All rights reserved.

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Fig. 6 — DNA sequence analysis of vivo-MO-1. (A) EV-71 was serially passaged in the presence of vivo-MO-1 from 1 μM to 5 μM. EV-71 populations that showed resistance to vivo-MO-1 were plaque purified, and subjected to DNA sequencing. Analysis of the vivo-MO-1 resistant mutant showed a T to C substitution at position 533. (B) The effect of sequence mismatches between vivo-MO-1 and target RNA on inhibition assay. Several in vitro transcribed RNA, each having a different number of nucleotide mismatches in the target region as described in Section 2 were analyzed. Viral titers were quantitated 24 hpi using standard plaque assay. The data presented were obtained from at least two independent biological replicates.