Table 2.
Pharmacokinetic parameter of chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, 3,4-dicaffeoylquinic acid and 3,5-dicaffeoylquinic acid in rats after oral administration of Flos Lonicerae extracts with or without the addition of COS (mean ± S.D., n = 5).
| Cmax (ng/ml) | Tmax (min) | AUC0–480min (ng min/ml) | Enhancement ratio | ||
|---|---|---|---|---|---|
| Neochlorogenic acid | Control | 149.05 ± 33.40 | 24.00 ± 8.22 | 13,988.00 ± 5215.62 | – |
| COS | 223.72 ± 80.87 | 14 ± 4.18 | 26,138.20 ± 7557.43* | 1.87 | |
| Chlorogenic acid | Control | 236.45 ± 61.18 | 30.00 ± 0.00 | 32,430.33 ± 7650.92 | – |
| COS | 283.73 ± 76.84 | 13.75 ± 4.79 | 39,458.00 ± 6080.64* | 1.22 | |
| Cryptochlorogenic acid | Control | 134.94 ± 49.24 | 30.00 ± 10.00 | 14,315.00 ± 1097.43 | – |
| COS | 151.47 ± 64.79 | 14.00 ± 4.18 | 27,442.00 ± 2691.25* | 1.92 | |
| 3,5-Dicaffeoylquinic acid | Control | 73.30 ± 28.58 | 36.25 ± 12.50 | 16,235.00 ± 4632.96 | – |
| COS | 137.80 ± 50.60 | 22.50 ± 5.00 | 26,936.00 ± 3834.91* | 1.70 | |
| 3,4-Dicaffeoylquinic acid | Control | 65.77 ± 36.48 | 27.50 ± 5.00 | 14,714.67 ± 2595.60 | – |
| COS | 96.60 ± 41.33 | 17.50 ± 2.89 | 26,052.00 ± 2140.68* | 1.77 |
*p < 0.05 and **p < 0.01 compared with the control group.