Scheme 4.
Reagents and conditions: (a) 3% HCHO, HCl, H2O; (b) CH3OH, HCl; (c) substituted benzoyl chlorides, pyridine, 25 °C; (d) benzyl bromide, NMP, Na2CO3, H2O; (e) LiOH, THF/CH3OH/H2O = 3:1:1, 25 °C; (f) LiOH, THF/CH3OH/H2O = 3:1:1, 80 °C.
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