Table 2.
Compound | IC50 (μM)a | Ki (μM) | EC50 (μM) | CC50 (μM)b | S.I.c |
---|---|---|---|---|---|
1a | >100 | NDd | —e | ND | |
3c | 13 | NDd | —e | ND | |
18a | 10 | 6.44 ± 0.8 | 18.86 | >200 | >10 |
18b | 5 | 2.48 ± 0.89 | 9.45 | >200 | >20 |
18c | 1 | 0.52 ± 0.024 | 0.18 | >200 | >1000 |
18d | 10 | 9.049 ± 2.35 | 0.11 | >200 | >1000 |
18e | 7 | 3.046 ± 0.61 | 0.16 | >200 | >1000 |
The highest concentration of samples is 10 μM in the assay against the SARS-CoV 3CL protease.
The highest concentration of sample is 200 μM in the assay of cytotoxicity on Vero E6 cells.
Selectivity index, the ratio of CC50 to EC50.
Not determined.
No protective effect against infection of Vero E6 cells at the concentration of 10 μM.