TABLE 1.
Histologic Features of the Lung in 8 Autopsy Cases of SARS
| Case Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|
| Sex/age | F/67 | M/63 | M/43 | M/38 | M/68 | M/50 | F/29 | M/39 |
| Illness (days) | 4 | 6 | 8 | 10 | 16 | 16 | 18 | 20 |
| DAD, acute | + | + | + | + | + | + | + | + |
| % | 2 | 4 | 3 | 3 | 1 | 1 | 3 | 1 |
| grade | 2 | 3 | 2 | 1 | 1 | 1 | 3 | 3 |
| Airspace edema | + | + | + | + | + | − | − | − |
| % | 3 | 4 | 3 | 4 | 2 | − | − | − |
| grade | 2 | 2 | 3 | 2 | 2 | − | − | − |
| Bronchiolar fibrin | + | − | + | + | − | − | − | − |
| DAD, organizing | − | + | − | − | − | + | + | + |
| % | − | 1 | − | − | − | 4 | 4 | 4 |
| grade | − | 1 | − | − | − | 3 | 3 | 3 |
| Pneumocyte hyperplasia | − | + | − | − | + | + | + | + |
| % | − | 2 | − | − | 1 | 4 | 3 | 4 |
| grade | − | 3 | − | − | 1 | 2 | 3 | 2 |
| Squamous metaplasia | − | + | − | − | + | + | + | + |
| Multinucleated cells | − | + | − | − | − | + | + | + |
| Acute bronchopneumonia | − | + | − | − | + | + | + | + |
| % | − | 2 | − | − | 3 | 4 | 2 | 4 |
| grade | − | 1 | − | − | 1 | 3 | 2 | 3 |
| Infarct | − | − | − | − | − | + | + | − |
| % | − | − | − | − | − | 1 | 1 | − |
| Hemorrhage | + | − | − | + | + | + | + | + |
| % | 2 | − | − | 2 | 1 | 3 | 2 | 3 |
| Fibrin thrombi | − | + | + | − | − | + | + | + |
| Cytopathic effect | − | − | − | − | − | − | − | − |
| Hemophagocytosis | − | − | − | − | − | − | − | − |
| Special stains | − | + | − | − | − | + | − | − |
| Viral immunos | − | − | − | − | − | − | − | − |
%: 1 = 1 − 24%, 2 = 25 − 49%, 3 = 50 − 74%, 4 =75 − 100% parenchymal involvement.
Grade: 1 = mild, 2 = moderate, 3 = marked.