Table II.
Criteria for evaluation of disease severity∗
| Attack severity | Score |
|---|---|
| Mild attacks (discomfort noticed, but no disruption of normal daily activity) | 0.5 for each 24 hours |
| Moderate attacks (discomfort sufficient to reduce or affect normal daily activity) | 1 for each 24 hours |
| Severe attacks (inability to work or perform daily activity) | 2 for each 24 hours |
| Need for treatment | |
| Emergency treatment: conservative, substitutive (C1-INH, FFP) | 5 each |
| Emergency treatment: invasive (intubation, tracheotomy) | 25 each |
| Long-term prophylaxis for more than 6 months | 25 |
| Long-term prophylaxis for 3-6 months | 12.5 |
| Score | Class | Degree |
|---|---|---|
| >30 | 1 | Severe |
| 21-30 | 2 | Moderate |
| 11-20 | 3 | Mild |
| 1-10 | 4 | Minimal |
| 0 | 5 | Asymptomatic |
∗
These parameters are determined over the period of 1 year. The sum of the scores defines the severity of the disease for that year.