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Involvement of P38 phosphorylation in the adipogenesis differentiation-enhancing effect of IL6R. (A, C) After IL6R knockout, the activation of P38 pathway was inhibited and there was no significant change in ERK or JNK. (B, D) After IL6R overexpression, the activation of P38 pathway was enhanced, and ERK as well as JNK showed no significant changes. (E) Oil Red O staining on day 10 of adipogenesis differentiation was significantly reduced by SB203580. * represents p<0.05.
