Table 1.

Commonalities and diversities of EVs

Features\Type of vesicle	Exosome	Ectosome or Microvesicle or Microparticle	Apoptotic body
The most frequent biomarkers	CD9, CD63, CD81 (15), Alix (16), Tsg101 (16, 17)	No common marker (18)	Annexin V, Phosphatidylserine, Thrombospondin, C3b (19)
Size (nm)	30∼100	100∼1000	500∼4000
Stemed from	Intraluminal microvesicles which are originated from endosomal pathway, pass through plasma membrane via exocytosis	Plasma membrane budding of activated cells including human neutrophils, tumor cells, erythrocytes, and polymorphonuclear leukocytes (20)	Plasma membrane of apoptotic cells containing cell fragments