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. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: J Am Chem Soc. 2019 Jun 28;141(27):10821–10829. doi: 10.1021/jacs.9b04655

Figure 3.

Figure 3.

In silico pol and exo mutations suggest cooperativity between active sites. We find that either exo or pol mutations perturb local and nonlocal regions. This includes residues adjacent to active site residues. (A) Residue stability SD is plotted with finger and exo domain mutations in red and green, respectively. A regional average of 30 amino acids was used. (B,C) Hypervariable regions displayed are ranges A, B, and residues 900–1050 referred to as the new hypervariable region (NHR). These are mapped on the Pol γ complex according to the domain/subdomain coloring scheme.