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. 2016 Jan 20;2016(1):CD008969. doi: 10.1002/14651858.CD008969.pub3

Summary of findings for the main comparison. Brief intervention compared to information provision for substance‐using adolescents.

Brief intervention compared to information provision for substance‐using adolescents
Patient or population: Substance‐using adolescents
 Settings: High schools or further education training colleges
 Intervention: Brief intervention
 Comparison: Information provision
Outcomes Illustrative comparative risks* (95% CI) Estimate effect
 (95% CI) No of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Information provision Brief intervention
Alcohol frequency 
 Self report questionnaires
 Medium‐term follow‐up: 4 to 6 months See comment The standardised mean alcohol frequency in the intervention groups was 0.01 standard deviations lower 
 (0.20 lower to 0.18 higher) SMD ‐0.01 (‐0.20 to 0.18) 434
 (2 studies) ⊕⊕⊕⊝
 moderate1 Number of days of alcohol use
Alcohol quantity 
 Self report questionnaires
Medium‐term follow‐up: 4 to 6 months
See comment The standardised mean alcohol quantity in the intervention groups was 0.14 standard deviations lower 
 (0.33 lower to 0.05 higher) SMD ‐0.14 (‐0.33 to 0.05) 434
 (2 studies) ⊕⊕⊕⊝
 moderate1 Number of standard alcohol units
Cannabis dependence 
 Self report questionnaires
 Short‐term follow‐up: 1 to 3 months See comment The standardised mean cannabis dependence score in the intervention groups was 0.09 standard deviations lower
(0.27 lower to 0.09 higher)
SMD ‐0.09 (‐0.27 to 0.09) 470
 (2 studies) ⊕⊕⊕⊝
 moderate1 Mean dependence score
Cannabis frequency 
 Self report questionnaires
 Short‐term follow‐up: 1 to 3 months See comment The mean cannabis frequency in the intervention groups was
 0.07 standard deviations lower 
 (0.25 lower to 0.11 higher) SMD ‐0.07 (‐0.25 to 0.11) 470
 (2 studies) ⊕⊕⊕⊝
 moderate1 Number of days cannabis use
Secondary outcomes related to substance use 
 Self report questionnaires
Short‐term follow‐up: 1 to 3 months
See comment The mean behavioural outcomes related to substance use in the intervention groups was
 ‐0.01 standard deviations lower 
 (0.19 lower to 0.17 higher) SMD ‐0.01 (‐0.19 to 0.17) 470
 (2 studies) ⊕⊕⊕⊝
 moderate1 Interactional Problems Score
*The basis for the assumed risk (e.g. the mean control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the estimate effect of the intervention (and its 95% CI). The estimate effects for certain outcomes were not estimable due to only one study assessing the specific outcome, or extremely high levels of heterogeneity making effects across studies difficult to compare.
 CI: confidence interval; SMD: standardised mean difference
GRADE Working Group grades of evidence
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.

1Risk of bias (‐1): It was not possible to blind the participants in all of the included studies. There was also uncertainty in two of the studies about allocation concealment and blinding of outcome assessor (Walker 2011; Werch 2005).