Barret 1999.

Methods	RCT, double‐blind
Participants	94 children (mean age 7.5 years) admitted to a US burn centre, ages between 1 and 18 years, n = 60 male. Burns > 40% TBSA + > 10% full‐thickness (third‐degree). Admitted within 3 days of injury. At least 1 donor site required.
Interventions	rhGH 0.2 mg/kg/day (n = 45) or saline as a placebo (n = 49) administered by subcutaneous injection for the entire acute‐phase hospital stay (mean = 34.5 days, SD = 52.3)
Outcomes	Burn Scar Rating Scale (Yeong 1997), % of people requiring reconstruction, number of plastic surgery operations in the first 2 years, time from injury to reconstructive operations in months. Burn scars were assessed by 3 experienced burn surgeons.
Funding	Not reported
Notes	Kappa interrater agreement was 0.78 for surface, 0.80 for border height, 0.72 for thickness, 0.81 for colour difference Only medians and ranges are given for Burn Scar Rating Scale categories, operations per patient and time from injury to reconstruction Ranges should not be used to estimate standard deviations (Higgins 2011b) The contacted authors could not provide additional data. Only data on percentage of people requiring reconstruction were included in this review.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of randomisation not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Low risk	Observers were blinded to treatment
Incomplete outcome data (attrition bias) All outcomes	Low risk	Patient follow‐up was completed for 95% of the participants
Selective reporting (reporting bias)	Unclear risk	Unclear. Study protocol was not available.