| Methods |
RCT |
| Participants |
219 adults enrolled in the study, from a burn centre in China. 12 people were lost; 207 people were analysed. Mean age: 36 years; 168 males, 39 females. Mean TBSA 61.5%; mean TBSA second‐degree burn 32%; mean TBSA third‐degree burn 19.6%. Included scalds, flame burns, chemical burns and electric burns. people with severe associated injuries were excluded. |
| Interventions |
rhGH 0.19 IU/kg/day (Gene Science®) (n = 112) or placebo saline (n = 95) were administered daily by subcutaneous injection morning or night beginning after a mean of 7.3 (SD = 2.8) days after injury and continuing for 10 to 16 days |
| Outcomes |
Mortality, hyperglycaemia (fasting blood‐glucose ≥ 10 mmol/L), septicaemia |
| Funding |
|
| Notes |
Article in Chinese. Informed consent for the study was obtained from participants or relatives. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
"Randomised blocks", no further details reported |
| Allocation concealment (selection bias) |
Unclear risk |
Not reported |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Method of blinding not reported |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
219 adults were enrolled in the study, 12 participants were lost or rejected and 207 participants were analysed |
| Selective reporting (reporting bias) |
Unclear risk |
Unclear. Study protocol was not available. |
