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Intestinal and systemic IgA and IgG ASC responses at PCD 0 and protective immunity induced by combined vaccine regimens in gnotobiotic pigsa
| Vaccine group | Mean no. ASC/5 × 105 MNC |
Protection rate against challenge |
||||||||||
| Intestinal lamina propria |
Spleen |
Diarrhea (%) | Shedding (%) | |||||||||
| IgA | IgG | IgA | IgG | |||||||||
| Combined regimens | ||||||||||||
| AttHRV/VLP2× | 135 | 67 | 6 | 4 | 44 | 58 | ||||||
| VLP2/AttHRV1× | 16 | 11 | 4 | 15 | 25 | 17 | ||||||
| Controls | ||||||||||||
| Wa 2/6-VLP+mLT IN 3× | 2 | 52 | 0 | 0 | 0 | 0 | ||||||
| AttHRV1× oral | 3 | 2 | 1 | 6 | 33 | 0 | ||||||
Data summarized from Yuan et al. (2001b).
