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. 2007 Jun 18;145(1):56–61. doi: 10.1016/j.jviromet.2007.05.012

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Copyright © 2007 Elsevier B.V. All rights reserved.

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Fig. 1 — Localized areas of infection (focus) visualized by PAP staining technique under a light microscope. At 8 h p.i., individual cells infected with KPEDV-9 are shown having dark-gray stained cytoplasm () due to reactivity of viral proteins deposited in the cytoplasm with anti-PEDV immune complex and DAB (A). At 10 h p.i., early signs of synyctium formation (multi-nucleated cells) and infection of adjacent cells (↑) are observed (B). At 12 h p.i., more than 50 nuclei () line up at the periphery of the syncytium (C). At 24 h p.i., there is nearly 100% cell-to-cell fusion through out the cell monolayer with the nuclei lined up in the middle of the syncytium () (D) (magnification: 40×).

Inline graphic — Localized areas of infection (focus) visualized by PAP staining technique under a light microscope. At 8 h p.i., individual cells infected with KPEDV-9 are shown having dark-gray stained cytoplasm () due to reactivity of viral proteins deposited in the cytoplasm with anti-PEDV immune complex and DAB (A). At 10 h p.i., early signs of synyctium formation (multi-nucleated cells) and infection of adjacent cells (↑) are observed (B). At 12 h p.i., more than 50 nuclei () line up at the periphery of the syncytium (C). At 24 h p.i., there is nearly 100% cell-to-cell fusion through out the cell monolayer with the nuclei lined up in the middle of the syncytium () (D) (magnification: 40×).