Table 2. GO and KEGG pathway enrichment analysis of DEGs in the most significant module.
The genes in the most significant module were mainly enriched in the function of cell cycle phase, mitosis, cell division, microtubule cytoskeleton, spindle, p53 signaling pathway, Oocyte meiosis.
| Pathway ID | Term | Count | P-value |
|---|---|---|---|
| GO:0000279 | M phase | 14 | 6.27E−18 |
| GO:0022403 | Cell cycle phase | 14 | 1.27E−16 |
| GO:0007067 | Mitosis | 11 | 4.12E−14 |
| GO:0000280 | Nuclear division | 11 | 4.12E−14 |
| GO:0051301 | Cell division | 10 | 4.04E−11 |
| GO:0015630 | Microtubule cytoskeleton | 9 | 1.90E−07 |
| GO:0005819 | Spindle | 6 | 1.04E−06 |
| GO:0051276 | Chromosome organization | 8 | 1.65E−06 |
| GO:0044430 | Cytoskeletal part | 9 | 1.22E−05 |
| GO:0003682 | Chromatin binding | 4 | 6.21E−04 |
| hsa04115 | p53 Signaling pathway | 3 | 0.003543755 |
| hsa04114 | Oocyte meiosis | 3 | 0.009071242 |
Note:
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes.