Fig. 6.1.

a Scheme of a light scattering setup. Light scattered by the particles over time at a scattering angle θ is focused onto a detector or detector-connected fiber cable for further downstream data processing. b Exemplary DLS data of an L-form DNAzyme (5′-GAAGTTAGCAACATCGATCGGAGGCGG-3′) in solution containing MES buffer as evaluated by the accompanying software. Autocorrelation function, half-logarithmic mean particle radius distribution and particle radius plot of the molecules are indicating a homogeneous monodisperse solution and a hydrodynamic radius of 2.4 ± 0.1 nm. Details about data processing are described in the following sections