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. Author manuscript; available in PMC: 2020 Jun 6.
Published in final edited form as: Science. 2019 Dec 6;366(6470):1251–1255. doi: 10.1126/science.aaz0898

Fig. 4. Human ipRGCs integrate extrinsic signals.

Fig. 4.

(A) Individual examples of conventional RGCs’ and type 1, 2, and 3 ipRGCs’ responses to increasing irradiance light pulses before (black traces) and after (color traces) application of synaptic blockers (30 s, 470 nm; irr1, irr2, irr3, and irr4: 2.9 × 1011, 3.5 × 1012, 2 × 1013, and 2 × 1014 photons/cm2 per second, respectively). Response properties before (black bars and symbols) and after (colored bars and symbols) application of synaptic blockers are shown in (B) and (C). (B) Threshold and latency (effect of irradiance: type 1, P < 0.05; type 2, P < 0.001; type 3, P < 0.001; effect of drugs: type 1, P < 0.01; type 2, P < 0.01; type 3, P < 0.001; two-way ANOVAs, Bonferroni post hoc tests). (C) Average ipRGCs’ sensitivity. In both (B) and (C): type 1, n = 9; type 2, n = 9; and type 3, n = 78. Error bars in (C) indicate SEM.