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. 2010 Jul 7;2010(7):CD002839. doi: 10.1002/14651858.CD002839.pub2

Comparison 1. Drug versus control in stroke: blood pressure lowering therapy.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Early death (≤ 1 month) 36 5134 Odds Ratio (IV, Random, 95% CI) 1.15 [0.98, 1.36]
1.1 ACE inhibitors (po) 3 164 Odds Ratio (IV, Random, 95% CI) 0.91 [0.26, 3.14]
1.2 Beta blockers (po) 5 434 Odds Ratio (IV, Random, 95% CI) 1.33 [0.58, 3.03]
1.3 Calcium channel blockers (iv) 6 738 Odds Ratio (IV, Random, 95% CI) 1.13 [0.76, 1.67]
1.4 Calcium channel blockers (po) 8 1802 Odds Ratio (IV, Random, 95% CI) 0.94 [0.63, 1.40]
1.5 Insulin (iv) 1 25 Odds Ratio (IV, Random, 95% CI) 3.00 [0.11, 80.95]
1.6 Magnesium (iv) 1 25 Odds Ratio (IV, Random, 95% CI) 1.05 [0.04, 29.24]
1.7 Naftidrofuryl 2 710 Odds Ratio (IV, Random, 95% CI) 1.16 [0.77, 1.75]
1.8 Nitric oxide 5 145 Odds Ratio (IV, Random, 95% CI) 1.00 [0.16, 6.11]
1.9 Piracetam 2 967 Odds Ratio (IV, Random, 95% CI) 1.38 [0.99, 1.92]
1.10 Prostacyclin (iv) 3 124 Odds Ratio (IV, Random, 95% CI) 0.51 [0.12, 2.23]
2 Death at end of trial 41 6648 Odds Ratio (IV, Random, 95% CI) 1.09 [0.96, 1.24]
2.1 ACE inhibitors (po) 3 155 Odds Ratio (IV, Random, 95% CI) 0.63 [0.21, 1.90]
2.2 ARA (po) 1 339 Odds Ratio (IV, Random, 95% CI) 0.38 [0.13, 1.11]
2.3 Beta blockers (po) 5 442 Odds Ratio (IV, Random, 95% CI) 1.10 [0.57, 2.14]
2.4 Calcium channel blockers (iv) 6 751 Odds Ratio (IV, Random, 95% CI) 1.17 [0.84, 1.63]
2.5 Calcium channel blockers (po) 10 1534 Odds Ratio (IV, Random, 95% CI) 0.97 [0.72, 1.29]
2.6 GKI (iv) 1 933 Odds Ratio (IV, Random, 95% CI) 1.14 [0.86, 1.51]
2.7 Magnesium (iv) 4 162 Odds Ratio (IV, Random, 95% CI) 0.64 [0.28, 1.48]
2.8 Naftidrofuryl 2 710 Odds Ratio (IV, Random, 95% CI) 1.19 [0.80, 1.77]
2.9 Nitric oxide 4 127 Odds Ratio (IV, Random, 95% CI) 1.01 [0.26, 4.00]
2.10 Pentoxifylline 0 0 Odds Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2.11 Piracetam 2 967 Odds Ratio (IV, Random, 95% CI) 1.32 [0.96, 1.81]
2.12 Prostacyclin (iv) 3 124 Odds Ratio (IV, Random, 95% CI) 0.96 [0.17, 5.38]
2.13 Unclassified or combined 1 404 Odds Ratio (IV, Random, 95% CI) 0.81 [0.44, 1.50]
3 Early death or deterioration (≤ 1month) 15 2175 Odds Ratio (IV, Random, 95% CI) 1.07 [0.90, 1.28]
3.1 ACE inhibitors (po) 0 0 Odds Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.2 Beta blockers (po) 4 357 Odds Ratio (IV, Random, 95% CI) 1.32 [0.84, 2.06]
3.3 Calcium channel blockers (iv) 3 254 Odds Ratio (IV, Random, 95% CI) 1.24 [0.75, 2.07]
3.4 Calcium channel blockers (po) 5 787 Odds Ratio (IV, Random, 95% CI) 1.04 [0.78, 1.39]
3.5 Magnesium (iv) 0 0 Odds Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.6 Naftidrofuryl 2 710 Odds Ratio (IV, Random, 95% CI) 0.96 [0.71, 1.32]
3.7 Nitric oxide 0 0 Odds Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.8 Piracetam 1 40 Odds Ratio (IV, Random, 95% CI) 0.21 [0.02, 2.25]
3.9 Prostacyclin (iv) 1 27 Odds Ratio (IV, Random, 95% CI) 1.96 [0.39, 9.93]
4 Death or disability at end of trial 29 3302 Odds Ratio (IV, Random, 95% CI) 1.11 [0.96, 1.29]
4.1 ACE inhibitors (po) 1 40 Odds Ratio (IV, Random, 95% CI) 1.11 [0.31, 4.03]
4.2 Beta blockers (po) 4 353 Odds Ratio (IV, Random, 95% CI) 1.19 [0.76, 1.85]
4.3 Calcium channel blockers (iv) 5 720 Odds Ratio (IV, Random, 95% CI) 1.13 [0.67, 1.91]
4.4 Calcium channel blockers (po) 6 1106 Odds Ratio (IV, Random, 95% CI) 1.30 [0.91, 1.86]
4.5 Magnesium (iv) 4 162 Odds Ratio (IV, Random, 95% CI) 0.73 [0.38, 1.43]
4.6 Naftidrofuryl 2 710 Odds Ratio (IV, Random, 95% CI) 0.97 [0.72, 1.32]
4.7 Nitric oxide 5 142 Odds Ratio (IV, Random, 95% CI) 1.31 [0.64, 2.65]
4.8 Piracetam 1 40 Odds Ratio (IV, Random, 95% CI) 0.37 [0.10, 1.36]
4.9 Prostacyclin (iv) 1 29 Odds Ratio (IV, Random, 95% CI) 2.60 [0.39, 17.16]
5 Systolic blood pressure, early 30 3473 Mean Difference (IV, Random, 95% CI) ‐6.95 [‐9.40, ‐4.51]
5.1 ACE inhibitors (po) 4 150 Mean Difference (IV, Random, 95% CI) ‐5.68 [‐18.32, 6.96]
5.2 ARA (po) 1 339 Mean Difference (IV, Random, 95% CI) ‐2.60 [‐6.92, 1.72]
5.3 Beta blockers (po) 5 397 Mean Difference (IV, Random, 95% CI) ‐6.14 [‐11.42, ‐0.87]
5.4 Calcium channel blockers (iv) 5 676 Mean Difference (IV, Random, 95% CI) ‐5.40 [‐12.86, 2.07]
5.5 Calcium channel blockers (po) 5 253 Mean Difference (IV, Random, 95% CI) ‐4.89 [‐11.01, 1.23]
5.6 GKI (iv) 1 933 Mean Difference (IV, Random, 95% CI) ‐11.10 [‐14.61, ‐7.59]
5.7 Insulin (iv) 1 25 Mean Difference (IV, Random, 95% CI) ‐2.20 [‐11.30, 6.90]
5.8 Magnesium (iv) 4 147 Mean Difference (IV, Random, 95% CI) ‐6.32 [‐14.64, 2.01]
5.9 Nitric oxide 5 145 Mean Difference (IV, Random, 95% CI) ‐10.32 [‐17.62, ‐3.02]
5.10 Other vasodilators (po) 1 4 Mean Difference (IV, Random, 95% CI) ‐7.16 [‐17.11, 2.79]
5.11 Unclassified or combined 1 404 Mean Difference (IV, Random, 95% CI) ‐14.0 [‐17.20, ‐10.80]
6 Systolic blood pressure, late 35 5175 Mean Difference (IV, Random, 95% CI) ‐4.60 [‐6.64, ‐2.57]
6.1 ACE inhibitors (po) 2 29 Mean Difference (IV, Random, 95% CI) ‐8.70 [‐30.37, 12.98]
6.2 Beta blockers (po) 4 338 Mean Difference (IV, Random, 95% CI) ‐4.92 [‐10.22, 0.37]
6.3 Calcium channel blockers (iv) 4 389 Mean Difference (IV, Random, 95% CI) ‐8.57 [‐19.08, 1.93]
6.4 Calcium channel blockers (po) 13 2119 Mean Difference (IV, Random, 95% CI) ‐3.21 [‐5.36, ‐1.06]
6.5 Insulin (iv) 1 25 Mean Difference (IV, Random, 95% CI) ‐4.90 [‐13.66, 3.86]
6.6 Magnesium (iv) 4 147 Mean Difference (IV, Random, 95% CI) 1.60 [‐10.62, 13.83]
6.7 Naftidrofuryl 2 698 Mean Difference (IV, Random, 95% CI) ‐1.67 [‐9.86, 6.52]
6.8 Nitric oxide 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.9 Other vasodilators 1 4 Mean Difference (IV, Random, 95% CI) ‐23.5 [‐45.32, ‐1.68]
6.10 Piracetam 2 854 Mean Difference (IV, Random, 95% CI) ‐2.46 [‐5.56, 0.64]
6.11 Prostacyclin (iv) 3 131 Mean Difference (IV, Random, 95% CI) ‐7.66 [‐15.55, 0.23]
6.12 Thiazide diuretics (po) 1 37 Mean Difference (IV, Random, 95% CI) ‐15.0 [‐34.25, 4.25]
6.13 Unclassified or combined 1 404 Mean Difference (IV, Random, 95% CI) ‐9.00 [‐14.03, ‐7.97]
7 Diastolic blood pressure, early 28 2135 Mean Difference (IV, Random, 95% CI) ‐2.53 [‐4.07, ‐0.99]
7.1 ACE inhibitors (po) 4 150 Mean Difference (IV, Random, 95% CI) ‐2.71 [‐6.94, 1.52]
7.2 ARA (po) 1 339 Mean Difference (IV, Random, 95% CI) ‐2.60 [‐5.57, 0.37]
7.3 Beta blockers (po) 5 397 Mean Difference (IV, Random, 95% CI) ‐2.46 [‐5.92, 1.00]
7.4 Calcium channel blockers (iv) 5 675 Mean Difference (IV, Random, 95% CI) ‐3.24 [‐9.26, 2.77]
7.5 Calcium channel blockers (po) 5 253 Mean Difference (IV, Random, 95% CI) ‐2.49 [‐5.64, 0.66]
7.6 Insulin (iv) 1 25 Mean Difference (IV, Random, 95% CI) 1.0 [‐6.10, 8.10]
7.7 Magnesium (iv) 4 147 Mean Difference (IV, Random, 95% CI) ‐3.53 [‐8.37, 1.30]
7.8 Nitric oxide 5 145 Mean Difference (IV, Random, 95% CI) ‐0.99 [‐5.43, 3.46]
7.9 Other vasodilators 1 4 Mean Difference (IV, Random, 95% CI) 2.67 [‐11.78, 17.12]
8 Diastolic blood pressure, late 34 4768 Mean Difference (IV, Random, 95% CI) ‐2.63 [‐3.90, ‐1.36]
8.1 ACE inhibitors (po) 2 29 Mean Difference (IV, Random, 95% CI) ‐2.64 [‐11.96, 6.69]
8.2 Beta blockers (po) 4 338 Mean Difference (IV, Random, 95% CI) ‐4.46 [‐7.77, ‐1.15]
8.3 Calcium channel blockers (iv) 4 389 Mean Difference (IV, Random, 95% CI) ‐5.35 [‐12.76, 2.06]
8.4 Calcium channel blockers (po) 13 2117 Mean Difference (IV, Random, 95% CI) ‐2.05 [‐3.45, ‐0.65]
8.5 Insulin (iv) 1 25 Mean Difference (IV, Random, 95% CI) ‐2.20 [‐7.57, 3.17]
8.6 Magnesium (iv) 4 147 Mean Difference (IV, Random, 95% CI) ‐2.61 [‐10.21, 5.00]
8.7 Naftidrofuryl 2 698 Mean Difference (IV, Random, 95% CI) ‐0.50 [‐6.23, 5.24]
8.8 Nitric oxide 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.9 Other vasodilators 1 4 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.10 Piracetam 2 853 Mean Difference (IV, Random, 95% CI) ‐0.69 [‐2.47, 1.09]
8.11 Prostacyclin (iv) 3 131 Mean Difference (IV, Random, 95% CI) ‐3.86 [‐8.12, 0.40]
8.12 Thiazide diuretics (po) 1 37 Mean Difference (IV, Random, 95% CI) ‐5.0 [‐16.00, 6.00]
9 Heart rate, early 20 1255 Mean Difference (IV, Random, 95% CI) ‐0.45 [‐3.06, 2.17]
9.1 ACE inhibitors (po) 3 62 Mean Difference (IV, Random, 95% CI) ‐1.25 [‐7.49, 4.99]
9.2 Beta blockers (po) 4 301 Mean Difference (IV, Random, 95% CI) ‐6.78 [‐9.61, ‐3.96]
9.3 Calcium channel blockers (iv) 3 379 Mean Difference (IV, Random, 95% CI) 0.91 [‐1.88, 3.70]
9.4 Calcium channel blockers (po) 3 217 Mean Difference (IV, Random, 95% CI) ‐2.17 [‐5.58, 1.23]
9.5 Magnesium (iv) 4 146 Mean Difference (IV, Random, 95% CI) ‐3.19 [‐12.60, 6.21]
9.6 Nitric oxide 5 145 Mean Difference (IV, Random, 95% CI) 6.27 [2.87, 9.66]
9.7 Other vasodilators 1 5 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Heart rate, late 26 2519 Mean Difference (IV, Random, 95% CI) ‐2.84 [‐4.55, ‐1.13]
10.1 ACE inhibitors (po) 2 31 Mean Difference (IV, Random, 95% CI) ‐11.55 [‐30.94, 7.85]
10.2 Beta blockers (po) 4 341 Mean Difference (IV, Random, 95% CI) ‐9.32 [‐12.00, ‐6.63]
10.3 Calcium channel blockers (iv) 4 365 Mean Difference (IV, Random, 95% CI) ‐0.13 [‐5.59, 5.32]
10.4 Calcium channel blockers (po) 10 1422 Mean Difference (IV, Random, 95% CI) ‐2.79 [‐3.86, ‐1.73]
10.5 Magnesium (iv) 4 145 Mean Difference (IV, Random, 95% CI) ‐4.32 [‐11.07, 2.42]
10.6 Naftidrofuryl 1 81 Mean Difference (IV, Random, 95% CI) 0.88 [‐5.78, 7.54]
10.7 Nitric oxide 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.8 Other vasodilators 1 3 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.9 Prostacyclin (iv) 3 131 Mean Difference (IV, Random, 95% CI) 7.61 [‐1.92, 17.13]