| Methods |
Single centre double‐blind, placebo‐controlled
Randomisation by computer (with minimisation on age and mean arterial BP)
ITT analysis |
| Participants |
UK
37 patients. T: 16, C: 21
Age: T: 76 years, C: 72 years
Male T: 6, C: 12
Inclusion: ischaemic or haemorrhage stroke
100% CT
Enrolment within 5 days: T: 4 patients enrolled > 5 days and C: 3 patients > 5 days
Stroke type assessed clinically |
| Interventions |
T: transdermal GTN 5 mg
C: matching placebo
Rx: 12 days |
| Outcomes |
24 hour ambulatory BP was measured before and during GTN treatment at days 0, 1 and 8
Ambulatory BP was monitored using a Spacelabs 90207 set to record thrice hourly during the day and hourly during the night
Functional outcome Rankin scale and Barthel Index and case fatality at 3 months
Late death and disability used Barthel, but if used Rankin there is 1 less missing value |
| Notes |
Ex: taking part in another trial |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Randomisation by computer (with minimisation on age and mean arterial BP) |
| Allocation concealment? |
Low risk |
Probably done |
| Blinding? |
Low risk |
Probably done |
| Completeness of follow‐up |
Low risk |
No loss of follow up |
