| Methods |
Multicentre, double‐blind, placebo‐controlled
Method of randomisation not known
ITT analysis |
| Participants |
Germany and Austria, 16 centres
482 patients: T: 239, C: 243
Age: 40 to 80 years
Inclusion: infarcts in anterior circulation
100% CT
Enrolment within 48 hours |
| Interventions |
T: po nimodipine 30 mg qid
C: matching placebo
Optional concomitant drugs were haemodilution, low‐dose heparin, acetylsalicylic acid, digitalis, diuretics, antihypertensives, and sedatives
Rx: 21 days |
| Outcomes |
Modified Mathew scale at baseline and days 1, 3, 5, 7, 14, 21 and 6 months
Barthel Index at days 1 and 21.
Method for measuring BP not given
BP estimated from graphs in paper |
| Notes |
Ex: TIA, progressive stroke, vertebrobasilar ischaemia, coma, intracerebral bleeding or tumour, SAH, pregnancy, cardiac surgery within last 3 months, severe systemic illness, acute severe hepatic disease, bradycardia < 50 beats/minute, hypotension SBP < 100 mmHg, severe AV conduction block, renal insufficiency, severe systemic infections, severe cardiac insufficiency within last 3 months, other CCBs, PTX, naftidrofuryl, fetal bovine serum, piracetam, dihydroergotoxine, steroids and osmotic drugs
Data taken from the paper |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Probably done |
| Allocation concealment? |
Unclear risk |
Unclear from the publication |
| Blinding? |
Low risk |
Probably done |
| Completeness of follow‐up |
Unclear risk |
Unclear from the publication |
