| Methods |
Single centre, double‐blind, placebo‐controlled
Randomisation technique not stated
PP analysis
5 lost to FU
Withdrawals: T: 4, C: 1 |
| Participants |
Poland
30 patients: T: 15, C: 15
Mean age 61 years
16 male and 14 female
Inclusion: IS in the territory of the internal carotid artery
100% EEG and CSF pre‐entry
Enrolment 24 to 72 hours |
| Interventions |
T: PGI2 (Wellcome, UK, or Chinoin, WRL), daily 6 hour iv infusions at 2.5 to 5 ng/kg/min
C: glycine solvent
Rx: 2 weeks
All patients given low‐molecular‐weight dextran |
| Outcomes |
Death at 4 weeks, neurological impairment assessed using modified Matthew score assessed at baseline, after each infusion, 3, 4 and 12 weeks
Barthel and Rankin at 1, 2, 4, 12, 24 and 48 weeks |
| Notes |
Ex: heart failure, hyperglycaemia, uraemia, arrhythmia, hyperpyrexia, previous stroke, mild stroke |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Probably done |
| Allocation concealment? |
Unclear risk |
Unclear from the publication |
| Blinding? |
Low risk |
Probably done |
| Completeness of follow‐up |
High risk |
5 lost to follow up |
