| Methods |
Multicentre, double‐blind, placebo‐controlled
Randomisation by minimisation
Stratified by age and stroke severity
ITT and PP analysis |
| Participants |
UK, Netherlands, Sweden: 9 centres
620 patients: T: 313, C: 307
Age: T: 72 years, C: 72 years
Male: T: 161, C: 160
Inclusion: ACHI
100% CT
Enrolment within 48 hours |
| Interventions |
T: naftidrofuryl fumarate 633 mg/day iv continuous for 7 days then orally for 6 months
C: solvent and identical looking tablets
Rx: 6 months |
| Outcomes |
Death
Assessments were at entry and intervals to 1 year
Method used for BP measurement not given |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Randomisation by minimisation |
| Allocation concealment? |
Unclear risk |
Unclear from the publication |
| Blinding? |
Unclear risk |
Probably done |
| Completeness of follow‐up |
Unclear risk |
Unclear from the publication |
