| Methods |
Single centre
Randomisation done using standard algorithm by the local pharmacy production unit
Allocation to insulin or control done in an open label design |
| Participants |
UK
25 patients: T: 13, C: 12
Mean age: 75 years
Inclusion: acute ischaemic stroke
Enrolment: within 24 hours of ictus
100% CT scan |
| Interventions |
T: iv insulin at a variable rate adjusted for target glucose concentration of 5 to 8 mmol/l
C: iv crystalloid
Rx: 2 days |
| Outcomes |
Mortality at 1 month |
| Notes |
Ex: known insulin requiring DM, patients with severe metabolic derangement, patients with clinical evidence of infection or CCF |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Randomisation performed using standard algorithm by the local pharmacy production unit |
| Allocation concealment? |
Low risk |
Probably done |
| Blinding? |
High risk |
Open label design |
| Completeness of follow‐up |
Unclear risk |
25 patients recruited (T: 13, C: 12); no mention of loss of follow‐up |
