| Methods |
Multicentre, double‐blind, placebo‐controlled
Randomisation by predetermined randomisation list |
| Participants |
Sweden
295 patients: T1: 101, T2: 94, C: 100
Age: T1: 71.9 years , T2: 72.1 years, C: 71 years
Male: T1: 45, T2: 45, C: 45
Inclusion: clinical diagnosis of ischaemic stroke in the carotid artery territory
Enrolment: within 24 hours of ictus |
| Interventions |
T1: nimodipine iv 1 mg/hour for 5 days followed by oral nimodipine 30 mg qid for 16 days
T2: nimodipine iv 2 mg/hour for 5 days followed by po nimodipine 30 mg qid for 16 days
C: matching placebo |
| Outcomes |
Transformed Orgogozo score and transformed Barthel index score on the follow up at day 21 |
| Notes |
— |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Probably done |
| Allocation concealment? |
Low risk |
According to predetermined randomisation lists |
| Blinding? |
Low risk |
Probably done |
| Completeness of follow‐up |
High risk |
Probably not done
101 patients did not complete 21 days of treatment
This includes 2 trial withdrawals |
