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a Sequence and secondary structure of the DIS hairpin of HIV-1 subtypes A and F. Asterisks indicate nucleotides of the DIS palindrome. b Tertiary structure of the DIS-induced dimer. The region of dimerization is indicated by the shaded box. c, d structures of small moelcules targeting the DLS (c) Thymine-neomycin conjugate (Ennifar et al. 2013) whose targeting to the DIS is mediated through Watson-Crick base-pairing with A280 (shaded in a). d Linked neamine dimer (Bodlenner et al. 2007)
