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Secondary (a) and tertiary structure (b) of the HIV-1 frameshift sequence that maintains the ~20:1 ratio of Gag:Gag/pol proteins, comprising the slippery sequence and frameshift stimulatory signal. c Structure of the frameshift stimulator Bis[N-(3 dimethylaminopropyl)amidino]benzene tetrahydrochloride (RG501). Modified from Marcheschi et al. (2011). d Compound 4, a frameshift stimulator that inhibits HIV-1 replication (Ofori et al. 2014)
