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a, b 3D representations of the A-like topology assumed by the RREs of HIV-1 and HIV-2, respectively. In a, the proposed binding site for the Rev arginine-rich motif (ARM) is indicated. Designations I–V represent the individual stem-loops. c Schematic representation of DOTA-RBP, a bifunctional metallopeptide combining the Rev binding peptide (RBP) with a metal-chelating center (DOTA) that can be induced to release reactive oxygen species
