. 2019 Aug 7:355–374. doi: 10.1007/978-981-32-9413-4_20

Table 20.1.

First-line agents for standard first-line anti-tubercular therapy

Drug	Adult daily dose	Comment
Isoniazid	5 mg/kg	Give pyridoxine 10 mg daily to prevent peripheral neuropathy; if established peripheral neuropathy, give pyridoxine 50–75 mg daily
Isoniazid	5 mg/kg	Protect tablets from light
Rifampicin	10 mg/kg	Preferably given 30 min before food
Pyrazinamide	25 mg/kg	Avoid with active hepatic disease (see further discussion on drug-induced hepatitis, below); adjust dose for renal function
Ethambutol	15 mg/kg	Adjust dose for renal function
Ethambutol	15 mg/kg	Ocular examination to be done before and periodically during treatment