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. 2020 Mar 27;11:367. doi: 10.3389/fphar.2020.00367

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Copyright © 2020 Zhu, Li, Li, Zhang, Du, Hao, Li, Cao and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine (BBR) mediates BNIP3 expression by enhancing the binding of HIF-1α to the BNIP3 promoter. (A) A dual-luciferase reporter assay assessed the effects of BBR on HIF-1α and BNIP3 transcriptional activity in H9C2 cells. (B) A chromatin immunoprecipitation (ChIP) PCR analysis was used to show the effects of BBR on HIF-1α and BNIP3 promoter binding, and HIF-1α knockdown weakened their binding activity. 1, control group; 2, H/R group; 3, BBR+H/R group; 4, siNC+BBR+H/R group; 5, siHIF-1α+BBR+H/R group. The data are the means ± SD (n=3). ^*P < 0.05 compared to the control group; ^#P < 0.05 compared to the H/R group; ^&P < 0.05 compared to the BBR+H/R group.