Table 13.1.

Biochemical and cellular activities of selected flaviviral protease inhibitors discussed in this chapter

Compound	Dengue virus [μM]a		West Nile virus [μM]		Zika virus [μM]
	Biochemicalb	Cellular	Biochemicalb	Cellular	Biochemicalb	Cellular
1	IC50 = 1.1	Inactive
2	K i = 2.0		K i = 4.6
3	IC50 = 2.0	EC50 = 59.5 CC50 = 135	IC50 = 8.7	EC50 = 42.4 CC50 = 135
4	IC50 = 2.2
5	IC50 = 1.0	EC50 = 0.8 CC50 > 10
6	IC50 = 0.5
7	IC50 = 15.4	EC50 = 0.17 CC50 = 29.3
8	IC50 = 1.2	EC50 = 39.4 CC50 > 100
9	IC50 = 8.5		IC50 = 0.11
10	IC50 = 2.8	EC50 = 40 CC50 = 213	IC50 = 0.26	EC50 = 42.3 CC50 = 213	IC50 = 1.1
11	IC50 > 10	EC50 = 81.5 CC50 = 236	IC50 = 0.44	EC50 = 17 CC50 = 236	IC50 > 10
12			IC50 = 1.1
13					K i = 9.5
14	Inactive	EC50 = 0.8 CC50 = 54			IC50 = 21.6	EC50 = 13.0 CC50 > 40
15	IC50 > 10	EC50 > 100 CC50 = 257	IC50 = 0.74	EC50 = 107 CC50 = 257	IC50 = 0.82	EC50 ~ 50 CC50 = 257
16	K i = 0.051	EC50 = 30 CC50 > 100	K i = 0.082	EC50 = 38 CC50 > 100	K i = 0.040
17	K i = 0.078	EC50 = 19 CC50 > 100	K i = 0.16	EC50 > 50 CC50 > 100	IC50 = 2.1
18	K i = 0.012	EC50 = 20 CC50 > 100	K i = 0.039	EC50 = 23 CC50 > 100
19	IC50 = 0.028	EC50 = 7.1 CC50 > 100	IC50 = 0.12		IC50 = 1.0
20	IC50 = 0.18	EC50 = 3.4 CC50 = 100	IC50 = 0.56	EC50 = 15.6 CC50 > 100

^aActivities have been reported for various serotypes. The serotype with the best activity results is reported here

^bIf reported activities vary by method or report, the lowest (best) value is shown