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Diabetes increases both circulating ACE and ACE2 activities in the hypertensive mRen2.Lewis rat. Comparison of circulating ACE2 and ACE activities in female and male normotensive Lewis, hypertensive mRen2.Lewis, and diabetic (DB) mRen2.Lewis rats. Data are mean ± SEM; 5-6 per group ∗P < 0.05 versus non-diabetic mRen2.Lewis; ^P < 0.05 versus ACE2; +P < 0.05 versus female mRen2.Lewis. Activities are expressed as fmol/minute/ml serum. (Adapted from Yamaleyeva et al. [71])
