Fig. 6.

Betamethasone-exposed (BMS) offspring exhibit higher mean arterial pressure (MAP) and greater CSF dipeptidyl aminopeptidase (DPP 3) activity than non-exposed sheep. MAP was higher in BMS animals at 6 months of age (a). CSF Ang-(1-7) peptide levels were lower in BMS animals (b). CSF DPP 3 was two-fold higher in BMS animals as compared to controls (c). Ang-(1-7) peptide levels negatively correlate with DPP 3 activity in the CSF (r = −0.81, P = 0.01) (d). Data are mean ± SEM; 4-5 per group; ∗P < 0.05 or ∗∗∗P < 0.001 vs. controls. (Adapted from Marshall et al. [113])