Table 2.

FDA-Approved Uses of Interferons

Interferon α-2α (Roferon®)

Hairy cell leukemia

AIDS-related KS

Chronic hepatitis C a

Chronic phase, Philadelphia chromosome (Ph)-positive CML patients with CML

Who are minimally pretreated (within 1 yr)

Pegylated IFN-α-2α (PEGASYS®)

Chronic hepatitis C a

IFN-α-2β

Genital warts

Chronic hepatitis B

Chronic hepatitis C a

Hairy cell leukemia

AIDS-related KS

Adjuvant therapy for malignant melanoma

In combination with chemotherapy for non-Hodgkin’s lymphoma (follicular

Lymphoma)

Pegylated IFN-α-2β (PEG-Intron®)

Chronic hepatitis C a

IFN-α-n3 (Alferon®)

Condylomata acuminata

IFN-alfacon-1 (Infergen®)

Chronic hepatitis C

IFN-β-1α(Avonex®, Rebif®)

Relapsing forms of multiple sclerosis

IFN-β-1β(Betaseron®)

Relapsing-remitting multiple sclerosis

IFN-γ(Actimmune®)

Chronic granulomatous disease

Malignant osteopetrosis

aIn the treatment of chronic hepatitis C, unpegylated and pegylated IFN-α-2α and α-2β are given in combination with oral ribavirin except if ribavirin is contraindicated