Table 5.1.

Surviving sepsis campaign bundle

To be completed within 3 h	Measure lactate level
	Obtain blood culture prior to administration of antibiotics
	Administer broad-spectrum antibiotics
	Administer 30 mL/kg crystalloid for hypotension or lactate ≥4 mmol/L
To be completed within 6 h	Apply vasopressors for hypotension that does not respond to initial fluid resuscitation to maintain MAP ≥65 mmHg
	Remeasure lactate if initial lactate was elevated
	In persistent arterial hypotension despite volume resuscitation or initial lactate ≥4 mmol/L, RE-access volume status and tissue perfusion and document findings according to
	Repeat focused exam with respect to vital signs including mental status, cardiopulmonary including urination, capillary refill, pulse including tachycardia, and skin findings such as mottled skin
	Or two of the following:    (1) Measure CVP: at least ≥8 mmHg    (2) Measure ScvO2: ≥70%    (3) Bedside cardiovascular ultrasound    (4) Dynamic fluid responsiveness with PLR or mini-fluid challenge