Table 3.3.
Some key features in term of etiology, metabolic feature and clinical presentation that distinguish T1DM from T2DM
| Type | T1DM | T2DM |
|---|---|---|
| Etiology | ||
| • Autoimmune features |
Yes (e.g. islet cell antigens, GAD65 & 67) Moderate |
No Very strong (e.g. MODY) |
| • Genetic susceptibility | Viruses, diet and stress | Physical inactivity |
| • Environmental factors | ||
| Metabolic features | ||
| • Insulin deficiency | Severe | Moderate |
| • Insulin resistance | Moderate | Severe |
| • Diabetic ketoacidosis | Yes | No |
| Clinical presentation | ||
|
• Age of onset • Body weight • Body mass index |
Most occur < 40 years old Commonly decrease Mostly <25 |
Most occur > 40 years Sometimes decrease Mostly >25 |