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Electron micrograph of negatively stained microsomal vesicles prepared from the endoplasmic reticulum of canine pancreatic acinar cells. Such microsomes are competent to cotranslationally translocate secretory and membrane proteins. Note that each microsomal vesicle has many ribosomes bound to its surface, indicating that each vesicle has multiple protein insertion sites. This is a prerequisite for the assembly of an oligomeric connexon within microsomes. Scale bar = 500 nm.
