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. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: Basic Res Cardiol. 2019 Jan 17;114(2):9. doi: 10.1007/s00395-019-0718-1

Fig. 1.

Fig. 1

a Cardiosphere-derived cell (CDC) biodistribution following MI/R. Representative biofluorescence images of organs harvested from rats treated intravenously with PBS or CDCs (DiD-labeled; 1.0 × 106) 2 h into reperfusion. b Quantification of total CDC biofluorescence relative to control tissue (n = 4). c Ischemic heart failure protocol. Myocardial ischemic reperfusion injury protocol in SHR. Rats were subjected to 45 min of coronary artery ligation followed by 12 weeks of reperfusion. SHR were treated with either PBS or 0.5 × 106 CDCs via intracardiac delivery with aortic cross-clamp 20 min into reperfusion. SHR were then treated with either PBS or 1.0 × 106 CDCs via tail vein injection at 2, 4, and 8 weeks. d LV ejection fraction, e LV end-diastolic dimensions, and f LV end-systolic dimensions. Mean is represented as ± SEM. *p < 0.05 compared to PBS, **p < 0.01 compared to PBS, ***p < 0.001 compared to PBS, and ****p < 0.001 compared to PBS